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Metformin HCl (1 1-Dimethylbiguanide HCl) decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis) Metformin promotes mitophagy in mononuclear cells Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153
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PF-562271 Besylate is the benzenesulfonate salt of PF-562271 which is a potent ATP-competitive reversible inhibitor of FAK with IC50 of 1 5 nM 10-fold less potent for Pyk2 than FAK and 100-fold selectivity against other protein kinases except for some CDKs Phase 1
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VU0467485 (AZ13713945) is a potent, selective, orally bioavailable positive allosteric modulator of the muscarinic acetylcholine receptor M4. It is supplied for research use and exhibits CNS penetration and antipsychotic-like activity in preclinical models.
Potent M4 positive allosteric modulator
Selective over M1, M2, M3, and M5 receptors
Orally bioavailable with CNS penetration
High purity suitable for research applications
Provided as a 100 mg pack for assay and preclinical studies
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
VU0467485 (AZ13713945) is a potent, selective, orally bioavailable positive allosteric modulator (PAM) of the muscarinic acetylcholine receptor M4 supplied as a solid research reagent for preclinical studies.
Potent and selective M4 receptor positive allosteric modulator.
Orally bioavailable in preclinical models.
High purity solid suitable for research applications.
Provided in small milligram pack sizes for preclinical dosing.
Molecular formula C17H17FN4O2S; molecular weight 360.41 g/mol.
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CUDA is a research-grade small-molecule inhibitor of soluble epoxide hydrolase (sEH) used in biochemical and cellular studies to probe sEH and PPAR-alpha pathways. It is supplied as a crystalline solid (CAS 479413-68-8) with molecular formula C19H36N2O3 and molecular weight 340.50 g/mol.
Potent sEH inhibitor with IC50 = 11.1 nM (mouse) and 112 nM (human).
High purity by HPLC (approximately 99.8%).
Supplied in small solid quantities suitable for assay development and cellular studies.
Soluble in common organic solvents for stock solution preparation.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More